Refractory epilepsy: a progressive, intractable but preventable condition?
نویسندگان
چکیده
منابع مشابه
Refractory epilepsy: a progressive, intractable but preventable condition?
Intractable seizures are just one manifestation of 'refractory epilepsy', which can be recognized as a distinct condition with multifaceted dimensions, including neurobiochemical plastic changes, cognitive decline and psychosocial dysfunction, leading to dependent behaviour and a restricted lifestyle. The biological basis of 'refractoriness' is likely to be multifactorial, and may include the s...
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Introduction Biotinidase deficiency is a life threatening inborn error of metabolism specially when delayed in diagnosis. We report a 2-month-old male infant that presented with refractory infantile spasm, alopecia and seborrheic dermatitis. With a high suspicion of the biotinidase deficiency we started biotin 10 mg daily orally before definite diagnosis was made. Rapid treatment was life-savin...
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Epilepsy is a chronic disease affects CNS in various ages. WHO estimates 50 million people are suffering from epilepsy worldwide which make it a serious prevalent problem among neurological diseases. Intractable epilepsy (IE) affects about 20-30% of epileptic patients who failed to be seizure - free after antiepileptic drug (AED) consumption. Although many AEDs now are available for epilepsy tr...
متن کاملDefinition of intractable epilepsy.
Defining intractable epilepsy is essential not only to identify up to 40% of patients refractory to pharmacological management, but also to facilitate selection and comparison of such patients for research purposes. The ideal definition still eludes us. Multiple factors including number of antiepileptic drug (AED) failures, seizure frequency and duration of unresponsiveness, etiology, and epile...
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CONTEXT Hemispherotomy is a surgical procedure for hemispheric disconnection. It is a technically demanding surgery. Our experience is presented here. AIMS To validate and compare the two techniques for hemispherotomy performed in patients with intractable epilepsies. SETTINGS AND DESIGN A retrospective study 2001-March 2007: Nineteen cases of hemispherotomies from a total of 462 cases oper...
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ژورنال
عنوان ژورنال: Seizure
سال: 2002
ISSN: 1059-1311
DOI: 10.1053/seiz.2002.0593